The CB1 receptors are concentrated in the brain & the central nervous system. CB1 receptors are linked to the endo-cannabinoid anandamide or the phyto-cannabinoid THC.
The CB2 receptors are mostly found in peripheral organs, especially cells of the immune system. CB2 receptors are related to the endo-cannabinoid 2-AG.
The TRPV1 receptors are concentrated in the blood, bone, marrow, tongue, kidney, liver, stomach and ovaries. These receptors influence temperature and pain.
The TRPV2 receptors are concentrated in the skin, muscles, kidney, stomach and lungs. It mediates cytokine release, phagocytosis, endocytosis, podosome assembly, and inflammation.
GPR 18 RECEPTOR
The GPR18 receptors can be found primarily in bone marrow, the spleen, lymph nodes, and to a lesser extend in the testes. It mediates in the immune system, and can be compared to an opioid receptor.
GPR 55 RECEPTOR
The GPR55 receptors are found in bones, the brain, the jejunum and Ileum. GPR55 is expressed in several prostate and ovarian cancer cell lines and has a critical role in regulating proliferation and growth. It is demonstrated to regulate bone cell function.
GPR 119 RECEPTOR
The GPR119 receptors are found predominantly in the pancreas and the intestinal tract, in small amounts. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats.
(ENDO)CANNABINOIDS is created by the Creative Embassy that interviewed many patients in order to make several scientific publications.